Cancer News
Most People Who Need a Marrow Transplant Will Find a Donor

Drugs to Avoid in Patients on Tyrosine Kinase Inhibitors

Ibrutinib and Idelalisib Coming to Europe Soon

What Is Driving Change in Oncology Clinical Practice?

Test Spares Men Unnecessary Biopsies for Prostate Cancer
Dyes used to paint new picture of disease

Tumorigenicity in induced pluripotent stem-cell based therapies significantly reduced

Barrett's esophagus less of a risk for those on statins

Stomach cancer has four subtypes, say scientists

FDA approves Zydelig for three types of blood cancers
Lymphoma Treatment May Harm, Halt Men's Sperm Production

Anal, Throat Cancers on the Rise Among Young Adults, Study Finds

Technique Used in Some Hysterectomies May Help Spread Cancer: Study

Can Bike Riding Up Prostate Cancer Risk?

FDA Advisers Weigh Risks of Procedure for Removal of Uterine Fibroids
Four Community Leaders Join Jonsson Cancer Center Foundation Board of Directors

UCLA's Jonsson Comprehensive Cancer Center Once Again Ranks Among Top 10 Cancer Centers Nationwide

Novel Robot-Assisted Surgery Technique Improves Removal of Small Kidney Cancer Tumors

UCLA Scientists Discover How Adult Stem Cell Regulation Contributes to Lung Cancer

Taking the Brakes off the Immune System to Fight Deadly Cancers
Impact of the National Breast and Cervical Cancer Early Detection Program on cervical cancer mortality among uninsured low-income women in the U.S., 1991–2007

SWOG0919: a Phase 2 study of idarubicin and cytarabine in combination with pravastatin for relapsed acute myeloid leukaemia

Decreased expression of cystathionine β-synthase promotes glioma tumorigenesis

Targeting survival and cell trafficking in multiple myeloma and Waldenstrom macroglobulinemia using pan-class I PI3K inhibitor, buparlisib

Relationship between primary colorectal tumour and location of colorectal liver metastases
2014 No.1 Jan - Mar - Research

Pengaruh Autoclave terhadap Properti Fisik dan Histopatologi Tulang: Sebuah Penelitian Dasar Rekonstruksi


1Department of Orthopaedic and Traumatology, Cipto Mangunkusumo Hospital Faculty of Medicine Universitas Indonesia
2Department of Patology AnatomyCipto Mangunkusumo Hospital Faculty of Medicine Universitas Indonesia

Diterima 19 Februari 2014; Direview 18 Maret 2014; Disetujui 27 Maret 2014


Background: Autoclave autograft is a promising alternative procedure in surgical treatment of bone tumors. A minimum effective autoclaving time of 15 minutes at 134°C to devitalise tumour cells. This study aims to know the effect of autoclave to physical properties and histopathology of bone.

Methods: We performed experimental study in 28 femoral bone of goat (Capra Aergagus circus) at age 1?2 year old. We divide into two groups with simple random sampling to be 14 autoclave and 14 control group. Autoclaving was performed to the bone at 134°C for 15 minute. We examined physical properties each 7 autoclave group to axial and bending force compared with physical properties of the control group. We also examined histopatology of the bone both groups. Independent t-test statistical analysis to evaluate the difference of axial and bending force between autoclave and control group.

Results: There were significant difference between autoclave and control group in axial force (p = 0.000) and bending force (p = 0.03). Physical properties of autoclave bone decreased 58.58 % in axial force and 20.33% bending force to control group. Histopathology examination revealed that all osteocytes were death in autoclave group but without matrix changes.

Conclusion: Autoclave at 134°C for 15 minute caused physical properties of bone decrease and statistically significant difference. It also made all osteocytes died but without matrix disturbance.

Keyword: Autoclave bone, Physical properties of bone.


Autograft yang mendapat pajanan autoclave merupakan salah satu prosedur alternatif dalam penatalaksanaan bedah tumor tulang. Pemanasan autoclave efektif untuk devitalisasi sel tumor pada suhu 134°C dalam waktu minimal 15 menit. Studi ini bertujuan untuk mengetahui pengaruh autoclave terhadap properti fisik dan histopatologi tulang.

Penelitian ini merupakan studi eksperimental terhadap 28 tulang kambing (Capra Aergagus circus) usia 1?2 tahun. Kami membagi menjadi dua kelompok dengan simple random sampling menjadi 14 kelompok autoclave dan 14 kelompok kontrol. Autoclave dilakukan untuk tulang pada suhu 134°C selama 15 menit. Evaluasi properti fisik dilakukan terhadap masing-masing kelompok 7 sampel tulang untuk gaya axial dan gaya bending. Kami juga memeriksa histopatologi tulang kedua kelompok. Analisis t-test independent statistik untuk mengevaluasi perbedaan axial dan gaya bending antara autoclave dan kelompok kontrol.

Hasil penelitian menunjukkan terdapat perbedaan yang bermakna antara kelompok autoclave dengan kelompok kontrol pada uji gaya axial (p = 0,000) dan gaya bending (p = 0,03). Properti fisik tulang diautoclave menurun 58,58% pada gaya axial dan 20,33% pada gaya bending. Pemeriksaan histopatologi menunjukkan kematian osteosit pada kelompok autoclave.

Penelitian ini menyimpulkan bahwa autoclave mengurangi kekuatan mekanik tulang, baik terhadap gaya axial maupun gaya bending dan bermakna secara statistik, serta menyebabkan kematian seluruh osteosit.

Kata Kunci: tulang autoclave, properti fisik tulang.


Click here to read / download the full content
(the article will appear in a new tab / window).

General - News & Events

Call for Paper

IJoC Call for Paper

Click above or here to enlarge / download.
(it will appear in a new tab / window).

General - General


cover laporan 2003-2007
Registrasi Kanker Berbasis Rumah Sakit di RSKD - 2003-2007

cover laporan 1993-1997
Registrasi Kanker Berbasis Rumah Sakit di RSKD - 1993-1997